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Rabbit Anti-CHRNB2/PE Conjugated antibody
Rabbit Anti-CHRNB2/PE Conjugated antibody
Nicotinic Acetylcholine Receptor beta 2; Acetylcholine receptor beta 2 neural; ACHB2_HUMAN; ACHN; Acrb 2; Acrb2; b2 nAchR; Cholinergic receptor nicotinic beta 2; Cholinergic receptor nicotinic beta polypeptide 2; Cholinergic receptor nicotinic beta polype
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  • NO.:SL4247R-PE
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Mouse,Rat,(predicted: Human,Chicken,Dog,Pig,Cow,)
    Applications:IF
    concentration:1mg/ml
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Product Name Anti-CHRNB2/PE
Chinese Name PE标记的烟碱型乙酰胆碱受体β2抗体
Alias Nicotinic Acetylcholine Receptor beta 2; Acetylcholine receptor beta 2 neural; ACHB2_HUMAN; ACHN; Acrb 2; Acrb2; b2 nAchR; Cholinergic receptor nicotinic beta 2; Cholinergic receptor nicotinic beta polypeptide 2; Cholinergic receptor nicotinic beta polypeptide 2 neuronal; CHRNB2; EFNL 3; EFNL3; nAChRB2; Neuronal acetylcholine receptor protein beta 2 chain precursor; Neuronal acetylcholine receptor protein subunit beta 2; Neuronal acetylcholine receptor subunit beta-2; Neuronal nicotinic acetylcholine receptor beta 2.  
Research Area Tumour  immunology  Neurobiology  Channel protein  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse, Rat,  (predicted: Human, Chicken, Dog, Pig, Cow, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 52kDa
Cellular localization The cell membrane 
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CHRNB2
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Neuronal acetylcholine receptors are homo- or heteropentameric complexes composed of homologous alpha and beta subunits. They belong to a superfamily of ligand-gated ion channels which allow the flow of sodium and potassium across the plasma membrane in response to ligands such as acetylcholine and nicotine. This gene encodes one of several beta subunits. Mutations in this gene are associated with autosomal dominant nocturnal frontal lobe epilepsy. [provided by RefSeq, Jul 2008]

Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subunit:
Neuronal AChR is composed of two different types of subunits: alpha and beta. Beta-2 subunit can be combined to alpha-2, alpha-3 or alpha-4 to give rise to functional receptors. Interacts with RIC3; which is required for proper folding and assembly.

Subcellular Location:
Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Similarity:
Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-2/CHRNB2 sub-subfamily.

Database links:

Entrez Gene: 1141 Human

Entrez Gene: 11444 Mouse

Entrez Gene: 54239 Rat

Omim: 118507 Human

SwissProt: P17787 Human

SwissProt: Q9ERK7 Mouse

SwissProt: P12390 Rat

Unigene: 2306 Human

Unigene: 35088 Mouse

Unigene: 53978 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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