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Rabbit Anti-Speedy protein C/PE-Cy7 Conjugated antibody
Rabbit Anti-Speedy protein C/PE-Cy7 Conjugated antibody
hSpy/Ringo C; Rapid inducer of G2/M progression in oocytes C; Rapid inducer of G2/M progression in oocytes, Xenopus, homolog of, C; RINGO C; Ringo2; SPDYC; SPDYC_HUMAN; speedy C; speedy homolog C; Speedy protein C; Speedy, Xenopus, homolog of, C.
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Details

Product Name Anti-Speedy protein C/PE-Cy7
Chinese Name PE-Cy7标记的快速周期蛋白C抗体
Alias hSpy/Ringo C; Rapid inducer of G2/M progression in oocytes C; Rapid inducer of G2/M progression in oocytes, Xenopus, homolog of, C; RINGO C; Ringo2; SPDYC; SPDYC_HUMAN; speedy C; speedy homolog C; Speedy protein C; Speedy, Xenopus, homolog of, C.  
Research Area Cell biology  Cyclin  Epigenetics  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, )
Applications ICC=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 33kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human Speedy protein C
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2.

Function:
Promotes progression through the cell cycle via binding and activation of CDK1 and CDK2. Involved in the spindle-assembly checkpoint. Required for recruitment of MAD2L1, BUBR1 and BUB1 to kinetochores. Required for the correctlocalization of the active form of Aurora B in prometaphase.

Subunit:
Interacts with CDK1 and CDK2. Interacts with AURKB.

Subcellular Location:
Nucleus.

Tissue Specificity:
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.

DISEASE:
Expressed in a variety of tissues including bone marrow, kidney, small intestine, liver, placenta and testis.

Similarity:
Belongs to the Speedy/Ringo family.

Database links:

Entrez Gene: 387778 Human

Omim: 614030 Human

SwissProt: Q5MJ68 Human

Unigene: 450642 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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