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Product Name Anti-FGF20/PE-Cy7 Chinese Name PE-Cy7标记的成纤维细胞生长因子20抗体 Alias FGF-20; Fgf20; FGF20_HUMAN; FGFK; Fibroblast Growth Factor 20. Research Area Tumour immunology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 23kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human FGF20. Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a member of the fibroblast growth factor family. The fibroblast growth factors possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene product is a secreted neurotrophic factor but lacks a typical signal peptide. It is expressed in normal brain, particularly the cerebellum, and may regulate central nervous system development and function. Homodimerization of this protein was shown to regulate its receptor binding activity and concentration gradient in the extracellular matrix. Genetic variations of this gene have been associated with Parkinson disease susceptibility. [provided by RefSeq, Oct 2009].
Function:
Neurotrophic factor that regulates central nervous development and function.
Subunit:
Homodimer. Interacts with FGFR2 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Tissue Specificity:
Predominantly expressed in the cerebellum.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:Entrez Gene: 26281 Human
Entrez Gene: 80857 Mouse
Omim: 605558 Human
SwissProt: Q9NP95 Human
SwissProt: Q9ESL9 Mouse
Unigene: 199905 Human
Unigene: 425526 Mouse
Unigene: 64492 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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