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Product Name Anti-SCLT1/PE-Cy5.5 Chinese Name PE-Cy5.5标记的钠离子通道相关蛋白1抗体 Alias CAP-1A; CAP1A; FLJ30655; hCAP-1A; SAP1; SCLT1; SCLT1_HUMAN; Sodium channel and clathrin linker 1; Sodium channel-associated protein 1. Research Area Cell biology Neurobiology Signal transduction Channel protein Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 81kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human SCLT1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.05M PB, pH 7.5. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
SCLT1 (sodium channel and clathrin linker 1), also known as CAP1A or hCAP-1A, is a 688 amino acid cytoplasmic protein that acts as a linker between the voltage-gated sodium channel, Na+ CP type X? and clathrin. SCLT1 is abundantly expressed in DRG (dorsal root ganglia) neurons and colocalizes with Na+ CP type X? SCLT1 regulates Na+ CP type X?channel activity by promoting channel internalization. SCLT1 exists as four alternatively spliced isoforms and is encoded by a gene located on human chromosome 4, which encodes nearly 6% of the human genome and has the largest gene deserts (regions of the genome with no protein encoding genes) of all human chromosomes. Defects in some of the genes located on chromosome 4 are associated with Huntington's disease, Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease.
Function:
Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization.
Subunit:
Interacts with SCN10A and clathrin. Identified in a complex containing SCN10A, clathrin and SCLT1 (By similarity).
Subcellular Location:
Cytoplasm. Cell periphery.
Database links:Entrez Gene: 132320 Human
Omim: 611399 Human
SwissProt: Q96NL6 Human
Unigene: 654690 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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