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Rabbit Anti-Calpain 1/PE-Cy5.5 Conjugated antibody
Rabbit Anti-Calpain 1/PE-Cy5.5 Conjugated antibody
Calcium activated neutral proteinase 1; Calpain1; Calpain-1; Calpain 1 catalytic subunit; Calpain large polypeptide L1; Calpain mu type; CANP 1; CANP; CANP1; CANPL1; CAPN 1; CAPN1; Cell proliferation inducing gene 30 protein; Cell proliferation inducing p
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  • NO.:SL1099R-PE-Cy5.5
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,Mouse,Rat,(predicted: Chicken,Pig,Cow,Sheep,)
    Applications:Flow-Cyt IF
    concentration:1mg/ml
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Product Name Anti-Calpain 1/PE-Cy5.5
Chinese Name PE-Cy5.5标记的钙蛋白酶1抗体
Alias Calcium activated neutral proteinase 1; Calpain1; Calpain-1; Calpain 1 catalytic subunit; Calpain large polypeptide L1; Calpain mu type; CANP 1; CANP; CANP1; CANPL1; CAPN 1; CAPN1; Cell proliferation inducing gene 30 protein; Cell proliferation inducing protein 30; Micromolar calpain; muCANP; muCL; Ca2 activated neutral protease; Calcium activated neutral proteinase small subunit; Calcium dependent protease small subunit 1; Calcium-activated neutral proteinase 1; Calpain 1 (mu/I) large subunit; Calpain 1 catalytic subunit; Calpain 1 large subunit; Calpain Large Polypeptide L1; Calpain Large Polypeptide L1; Calpain mu type; Calpain mu-type; Calpain regulatory subunit; Calpain small subunit 1; Calpain-1 catalytic subunit; Calpain-1 large subunit; Calpain1; CAN1_HUMAN.  
Research Area Signal transduction  Apoptosis  Kinases and Phosphatases  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat,  (predicted: Chicken, Pig, Cow, Sheep, )
Applications Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 78kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from mouse Calpain 1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Function:
Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction.

Subunit:
Forms a heterodimer with a small (regulatory) subunit (CAPNS1).

Subcellular Location:
Cytoplasm. Cell membrane. Translocates to the plasma membrane upon Ca(2+) binding.

Tissue Specificity:
Ubiquitous.

Post-translational modifications:
Undergoes calcium-induced successive autoproteolytic cleavages that generate a membrane-bound 78 kDa active form and an intracellular 75 kDa active form. Calpastatin reduces with high efficiency the transition from 78 kDa to 75 kDa calpain forms.

Similarity:
Belongs to the peptidase C2 family. Contains 1 calpain catalytic domain. Contains 4 EF-hand domains.

Database links:

Entrez Gene: 12333 Mouse

Entrez Gene: 823 Human

Entrez Gene: 29153 Rat

Omim: 114220 Human

SwissProt: P07384 Human

SwissProt: O35350 Mouse

SwissProt: P97571 Rat

Unigene: 502842 Human

Unigene: 6221 Mouse

Unigene: 6037 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

钙蛋白酶(calpain)是一族钙离子依赖性的、水解半胱氨酸的蛋白酶,广泛存在于全身各脏器组织中。钙蛋白酶参与不同细胞过程,包括Cytoskeleton和The cell membrane附着的构型重建、不同的Signal transduction途径和Apoptosis等.

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