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Rabbit Anti-CTGF/PE-Cy5.5 Conjugated antibody
Rabbit Anti-CTGF/PE-Cy5.5 Conjugated antibody
CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; CTGF; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tis
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  • NO.:SL0743R-PE-Cy5.5
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Human,Mouse,Rat,(predicted: Chicken,Dog,Pig,Cow,)
    Applications:IF
    concentration:1mg/ml
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Product Name Anti-CTGF/PE-Cy5.5
Chinese Name PE-Cy5.5标记的结缔组织生长因子抗体
Alias CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; CTGF; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN.  
Research Area Cardiovascular  immunology  Growth factors and hormones  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, )
Applications IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 36kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human CTGF (202-241aa)
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009].

Function:
Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.

Subunit:
Monomer.

Subcellular Location:
Secreted, extracellular space, extracellular matrix. Secreted.

Tissue Specificity:
Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested.

Similarity:
Belongs to the CCN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
Contains 1 IGFBP N-terminal domain.
Contains 1 TSP type-1 domain.
Contains 1 VWFC domain.

Database links:

Entrez Gene: 1490 Human

Entrez Gene: 64032 Rat

Omim: 121009 Human

SwissProt: P29279 Human

SwissProt: P29268 Mouse

SwissProt: Q9R1E9 Rat

Unigene: 410037 Human

Unigene: 390287 Mouse



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Growth factors and hormones( Growth Factor and Hormones)
结缔组织生长因子(CTGF)是调节细胞增生、分化和Extracellular matrix形成的重要效应分子,可调节机体有关组织、细胞生长并与纤维化发生密切相关的一种因子,因而在肌体的各类创伤修复过程中具有重要的生理学意义。

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