Product Name	Anti-E.coli O157:H7/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的肠出血性大肠杆菌埃希氏菌O157:H7抗体
Alias	Escherichia coli O157:H7; Enterohemorrhage E．Coli; EHEC
Research Area	immunology  Bacteria and viruses
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Escherichia Coli, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	Ecoli O157;H7 protein
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This antibody reacts with Escherichia coli O157 (E.coli O157), Escherichia coli is a gram negative bacillus that belongs to a larger group of Enterobacteriae - bacteria that inhabit the gastrointestinal tract. Although usually a harmless resident of the gut, some strains have the potential to cause serious problems, especially where there is an immature immune system or immunosuppression, or where the subtype of organism has acquired the ability to produce pathogenic toxins. Function: Escherichia coli are Gram negative bacterium that are commonly found in the lower intestine of warm-blooded organisms (endotherms). Their serological types are determined in combination with somatic antigens (O group: O1-O173) and flagella antigens (H type: H1-H56). The E. coli that cause intestinal infectious diseases including diarrhea, acute gastritis or colitis are referred to as pathogenic E. coli, which are classified into the following 4 groups according to differences in the mode of pathogenicity; enteropathogenic E. coli (EPEC), enteroinvasive E. coli (EIEC), enterotoxigenic E. coli (ETEC) and enterohemorrhagic E. coli (EHEC). Although the identification of pathogenic E. coli requires verification of their pathogenicity, pathogenic E. coli often have specific serotypes; therefore, typing of the serogroup and serotype is necessary in screening pathogenic E. coli. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.     EHEC-肠出血性大肠埃希氏菌O157:H7(E.coli O157:H7)为产肠毒素大肠杆菌埃希氏菌-肠出血致病性大肠埃希氏菌的一种与志贺痢疾杆菌I型产生的毒素相似。     EHEC主要侵犯结肠，在肠道能使肠粘膜细胞坏死，引起组织病变-形成肠壁溃疡； EHEC-大肠埃希氏菌O157：H7是毒力最强的一种，该毒株对很多抗菌素都有不同的耐、抗药性，严重者，可导致溶血性尿毒综合征症状,治疗不及时会引起死亡。     EHEC引起肠道侵袭性病变，主要在结肠部位。研究认为ETEC产生的志贺样毒素与肠壁组织的微vascular endothelial cell上的受体结合，引起血管损伤，同时激发局部cell factorTNF、LPS及IL1β增加。这些cell factor又增强受体对毒素的敏感性，促使血管损伤进一步加重。此毒素是否作用于其他脏器endothelial cells，激发产生cell factor，引起局部损伤-引起血管出血情况的现象有待进一步研究。

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