Product Name	Anti-MD1/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的MD-1蛋白抗体
Alias	BPAD; dJ80N2.1; LY86; LY-86; LY 86; Lymphocyte antigen 86; Lymphocyte antigen 86 precursor; Major affective disorder 1; MD-1; MD1; MD 1; MD1 protein; MD1 RP105 associated; MD1 RP105 associated; MMD-1; RP1-80N2.1.
Research Area	immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	16kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LY-86
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105. Function: May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression. Subcellular Location: Secreted. extracellular space. Associated with CD180 at the cell surface. Tissue Specificity: Highly expressed in B-cells, monocytes and tonsil. Database links: Entrez Gene: 9450 Human Entrez Gene: 17084 Mouse Entrez Gene: 396639 Pig Entrez Gene: 291359 Rat Omim: 605241 Human SwissProt: O95711 Human SwissProt: O88188 Mouse Unigene: 653138 Human Unigene: 2639 Mouse Unigene: 3176 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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