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Product Name Anti-SLAMF6/LY108/PE-Cy5.5 Chinese Name PE-Cy5.5标记的SLAMF6抗体 Alias LY108; Activating NK receptor; KALI; KALIb; MGC104953; NK T B antigen; NTB A; NTBA; SF2000; SLAM family member 6; SLAM family member 6 precursor; SLAMF6; SLAF6_HUMAN; NK-T-B-antigen; NTB-A; CD352. Research Area immunology Cell Surface Molecule Cell type markers Natural killer cells Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Rat, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 37kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from mouse SLAMF6 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
SLAMF6 is a type I transmembrane protein, belonging to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 is expressed on Natural killer (NK), T, and B lymphocytes. It undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. It can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients. It may play a role in the regulation of autoimmune diseases.
Function:
Triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors.
Subunit:
Homodimer. Interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP.
Subcellular Location:
Cell membrane; Single-pass type I membrane protein (Probable).
Tissue Specificity:
Expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes.
Similarity:
Contains 1 Ig-like (immunoglobulin-like) domain.
Database links:Entrez Gene: 114836 Human
Entrez Gene: 30925 Mouse
Omim: 606446 Human
SwissProt: Q96DU3 Human
SwissProt: Q9ET39 Mouse
Unigene: 492348 Human
Unigene: 486404 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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