Product Name	Anti-ANO1/TMEM16A/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的Transmembrane protein16A/钙激活氯离子通道抗体
Alias	ANO 1; ANO1; ANO1_HUMAN; Anoctamin 1; Anoctamin 1 calcium activated chloride channel; Anoctamin-1; Anoctamin1; Discovered on gastrointestinal stromal tumors protein 1; DOG 1; FLJ10261; Membrane protein; Oral cancer overexpressed 2; Oral cancer overexpressed protein 2; ORAOV 2; ORAOV2; TAOS 2; TAOS2; TMEM 16A; TMEM16A; Transmembrane protein 16A (eight membrane spanning domains); Transmembrane protein 16A; Tumor amplified and overexpressed sequence 2; Tumor-amplified and overexpressed sequence 2.
Research Area	Tumour  Cell biology  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	114kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DOG-1/TMEM16A
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: TMEM16A (Transmembrane protein 16A) is an eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products and is amplified in various cancers. It acts as a calcium-activated chloride channel and is required for normal tracheal development. Function: Acts as a calcium-activated chloride channel. Required for normal tracheal development (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein. Cytoplasm. Tissue Specificity: Broadly expressed with higher levels in liver and skeletal muscle. Similarity: Belongs to the anoctamin family. Database links: Entrez Gene: 55107 Human Entrez Gene: 101772 Mouse Entrez Gene: 309135 Rat Omim: 610108 Human SwissProt: Q5XXA6 Human SwissProt: Q8BHY3 Mouse Unigene: 503074 Human Unigene: 26700 Mouse Unigene: 162509 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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