Product Name	Anti-G protein beta 4/PE-Cy5.5
Chinese Name	PE-Cy5.5标记的G蛋白β4抗体/鸟嘌呤核苷酸Binding proteinβ亚基4
Alias	G protein beta 4 subunit; GNB 4; GNB4; Guanine nucleotide binding protein (G protein) beta polypeptide 4; Guanine nucleotide binding protein beta 4 subunit; Guanine nucleotide binding protein beta polypeptide 4; Guanine nucleotide binding protein beta subunit 4; Guanine nucleotide binding protein subunit beta 4; Transducin beta chain 4; GBB4_HUMAN.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  Binding protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	37kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G protein beta 4 (52-90aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Guanine nucleotide binding proteins (G proteins) are membrane associated, heterotrimeric proteins composed of three subunits: alpha, beta and gamma. The G protein beta subunit assumes a barrel shaped beta propeller structure containing WD40 repeats preceded by an N terminal alpha helix. The beta subunit forms a stable dimer with the gamma subunit. The alpha subunit only contacts the beta subunit in the dimer, lying on the opposite face from the gamma subunit. G proteins and their receptors (GPCRs) regulate systems as diverse as sensory perception, cell growth and hormonal regulation. Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Subunit: G proteins are composed of 3 units, alpha, beta and gamma. Tissue Specificity: Strongly expressed in lung and placenta, whereas it is weakly expressed in brain and heart. Similarity: Belongs to the WD repeat G protein beta family. Contains 7 WD repeats. Database links: Entrez Gene: 59345 Human Entrez Gene: 14696 Mouse Entrez Gene: 294962 Rat Omim: 610863 Human SwissProt: Q9HAV0 Human SwissProt: P29387 Mouse SwissProt: Q3THF3 Mouse SwissProt: Q3TY18 Mouse SwissProt: Q3U2F9 Mouse SwissProt: O35353 Rat SwissProt: Q4V8I8 Rat Unigene: 173030 Human Unigene: 139192 Mouse Unigene: 10844 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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