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Product Name Anti-GGT7 light chain/PE-Cy3 Chinese Name PE-Cy3标记的γ-谷氨酰转肽酶7轻链抗体 Alias Gamma-glutamyltransferase 7 light chain; D20S101; dJ18C9.2; Gamma glutamyltransferase 4; Gamma glutamyltransferase 7; Gamma glutamyltransferase like 3; Gamma glutamyltransferase like 5; Gamma glutamyltranspeptidase 7; Gamma glutamyltranspeptidase like 3; GGT 7; GGT4; GGTL3; GGTL5; GGT7_HUMAN. Research Area Tumour Cell biology Signal transduction Stem cells The new supersedes the old Transmembrane protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 21kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Gamma-glutamyltransferase 7 light chain Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene is a member of a gene family that encodes enzymes involved in both the metabolism of glutathione and in the transpeptidation of amino acids. Changes in the activity of gamma-glutamyltransferase may signal preneoplastic or toxic conditions in the liver or kidney. The protein encoded by this gene consists of a heavy and a light chain, and it can interact with CT120, a plasma membrane-associated protein that is possibly involved in lung carcinogenesis. [provided by RefSeq, Jul 2008].
Function:
Cleaves glutathione conjugates
Subunit:
Heterodimer composed of the light and heavy chains. The active site is located in the light chain. Isoform 3 interacts with FAM57A.
Subcellular Location:
Membrane; Single pass type II membrane protein.
Tissue Specificity:
Widely expressed, but at low level, except in the airway epithelial cells. Detected in brain, heart, kidney, liver, lung, spleen, testis and trachea.
Similarity:
Belongs to the gamma-glutamyltransferase family.
Database links:
UniProtKB/Swiss-Prot: Q9UJ14.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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