Product Name	Anti-HERC1 /PE-Cy3
Chinese Name	PE-Cy3标记的鸟苷酸释放因子p532蛋白抗体
Alias	Guanine nucleotide exchange factor p532; Hect (homologous to the E6 AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1) like domain (RLD) 1; HECT and RLD domain containing E3 ubiquitin protein ligase family member 1; HECT domain and RCC1 like domain containing protein 1; p532; p619; Probable E3 ubiquitin-protein ligase HERC1; HERC1_HUMAN.
Research Area	Cell biology  immunology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	532kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human HERC1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: HERC1 is a stimulates guanine nucleotide exchange on ARF1 and Rab proteins. This protein may be involved in membrane transport processes. Function: Involved in membrane trafficking via some guanine nucleotide exchange factor (GEF) activity and its ability to bind clathrin. Acts as a GEF for Arf and Rab, by exchanging bound GDP for free GTP. Binds phosphatidylinositol 4,5-bisphosphate, which is required for GEF activity. May also act as a E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Subunit: Interacts with TSC2; interaction is inhibited by TSC1. Interacts with PKM, ARF1 and ARF6. Forms a ternary complex with clathrin heavy chain (CLTC) and HSPA1A. Subcellular Location: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Golgi apparatus. Note=Recruited onto actin-rich surface protrusions. Tissue Specificity: Widely expressed. Similarity: Contains 1 B30.2/SPRY domain. Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 14 RCC1 repeats. Contains 11 WD repeats. Database links: Entrez Gene: 538029 Cow Entrez Gene: 8925 Human Entrez Gene: 235439 Mouse Entrez Gene: 100153537 Pig Entrez Gene: 315771 Rat Omim: 605109 Human SwissProt: Q15751 Human Unigene: 210385 Human Unigene: 244179 Mouse Unigene: 232088 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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