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Product Name Anti-GPR12 /PE-Cy3 Chinese Name PE-Cy3标记的G protein-coupled receptorGPR12蛋白抗体 Alias FLJ18149; FLJ97704; G protein coupled receptor 12; G-protein coupled receptor 12; GPCR12; GPCR21; GPR 12; GPR12_HUMAN; MGC138349; MGC138351; Probable G protein coupled receptor GPR12; GPCR 12. Research Area Cell biology immunology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 37kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPR12 protein Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
GPR12 is a 334 amino acid peptide that is expressed primarily in brain, particularly in regions where neuronal differentiation takes place. GPR12 is coupled to an inhibitory G protein. It positively influences differentiation and maturation of post-mitotic neurons, and it may promote the growth of neuronal precursor cells.
Function:
Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.
Subcellular Location:
Cell membrane; Multi-pass membrane protein (Probable).
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2835 Human
Entrez Gene: 14738 Mouse
Omim: 600752 Human
SwissProt: P47775 Human
SwissProt: P35412 Mouse
Unigene: 123034 Human
Unigene: 153539 Mouse
Unigene: 88417 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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