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Product Name Anti-GFPT2/PE-Cy3 Chinese Name PE-Cy3标记的D-果糖6磷酸转移酶2抗体 Alias D fructose 6 phosphate amidotransferase 2; GFAT 2; GFAT2; Glucosamine fructose 6 phosphate aminotransferase [isomerizing] 2; glutamine fructose 6 phosphate transaminase 2; Glutamine:fructose 6 phosphate amidotransferase 2; Hexosephosphate aminotransferase 2; GFPT2_HUMAN. Research Area Cardiovascular Cell biology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 77kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GFPT2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
GFPT2 (glutamine-fructose-6-phosphate transaminase 2), also known as D-fructose-6-phosphate amidotransferase 2 or hexosephosphate aminotransferase 2, is a 682 amino acid protein and isoenzyme of GFAT1, the first and rate-limiting enzyme for the entry of glucose into the hexosamine biosynthetic pathway (HBP), which is a relatively minor branch of glycolysis. Expressed in spinal cord, heart and placenta, GFAT2 regulates glucose entry into the HBP and likely controls the availability of precursors for N- and O-linked protein glycosylation. Containing one glutamine amidotransferase type-2 domain and two SIS domains. GFAT2 is encoded by a gene that maps to human chromosome 5q35.3. GFAT2 gene variants have been linked to type 2 diabetes, diabetic nephropathy, and increased GFPT2 mRNA levels.
Function:
GFPT2, also known as glutamine fructose 6 phosphate transaminase 2, controls the flux of glucose into the hexosamine pathway. It is probably involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins.
Tissue Specificity:
Highest levels of expression in heart, placenta, and spinal cord.
Similarity:
Contains 1 glutamine amidotransferase type-2 domain.
Contains 2 SIS domains.
Database links:Entrez Gene: 9945 Human
Entrez Gene: 14584 Mouse
Omim: 603865 Human
SwissProt: O94808 Human
SwissProt: Q9Z2Z9 Mouse
Unigene: 696497 Human
Unigene: 24402 Mouse
Unigene: 16089 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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