Product Name	Anti-GABA Transporter 2/PE-Cy3
Chinese Name	PE-Cy3标记的γ氨基丁酸运载蛋白2抗体
Alias	GABA transport protein; GAT 2; GAT-2; GAT2; Solute carrier family 6 (Neurotransmitter transporter, GABA), member 13; S6A13_HUMAN.
Research Area	Cell biology  Neurobiology  The cell membrane受体  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	68kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human GABA Transporter 2/GAT-2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: GABA is a major inhibitory neurotransmitter and the GABAergic transmission is terminated by the rapid Na+/Cl-dependent uptake of through GABA transporters. There are multiple subtypes of GABA transporters (GAT1, GAT2, GAT3; and betaine GABA transporter (BGT-1). There is ~50% homology between each subtypes. GAT1 and GAT3 have been detected in various parts of the brain while GAT2 is found in many tissues. It appears that GAT1 and GAT3 are involved in distinct GABAergic transmission while GAT2 may be important in non-neural functions. GAT2 is a gamma-amino butyric acid (GABA) transporter. It is a 602 amino acid (85kDa) transmembrane protein. Function: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed in brain, kidney, lung, liver and testis. Similarity: Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily. Database links: Entrez Gene: 6540 Human Entrez Gene: 14412 Mouse Entrez Gene: 171163 Rat SwissProt: Q8TCC2 Human SwissProt: Q9NSD5 Human SwissProt: P31649 Mouse SwissProt: P31646 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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