Product Name	Anti-SGLT1/PE-Cy3
Chinese Name	PE-Cy3标记的钠-糖共转运载体1抗体
Alias	D22S675; High affinity sodium glucose cotransporter 1; GLT1; GLT-1; High affinity sodium glucose cotransporter; Human Na+/glucose cotransporter 1; Na(+)/glucose cotransporter 1; NAGT; SGLT 1; SLC5A1; Sodium glucose cotransporter 1; Sodium/glucose cotransporter 1; Solute carrier family 5 (sodium/glucose cotransporter) member 1; Solute carrier family 5 member 1.
Research Area	Neurobiology  Transporter
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	73kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SGLT1
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene encodes a member of the sodium-dependent glucose transporter (SGLT) family. The encoded integral membrane protein is the primary mediator of dietary glucose and galactose uptake from the intestinal lumen. Mutations in this gene have been associated with glucose-galactose malabsorption. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] Function: Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2:1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Expressed mainly in intestine and kidney. Post-translational modifications: N-glycosylation is not necessary for the cotransporter function. DISEASE: Congenital glucose/galactose malabsorption (GGM) [MIM:606824]: Intestinal monosaccharide transporter deficiency. It is an autosomal recessive disorder manifesting itself within the first weeks of life. It is characterized by severe diarrhea and dehydration which are usually fatal unless glucose and galactose are eliminated from the diet. Note=The disease is caused by mutations affecting the gene represented in this entry. Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. Database links: Entrez Gene: 6523 Human Entrez Gene: 20537 Mouse Entrez Gene: 397113 Pig Entrez Gene: 25552 Rat Omim: 182380 Human SwissProt: P13866 Human SwissProt: Q8C3K6 Mouse SwissProt: P53790 Rat Unigene: 1964 Human Unigene: 25237 Mouse Unigene: 10224 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 葡萄糖的跨膜转运主要是通过SGLT1结合1 mol葡萄糖,2 mol的Na+,形成Na+-载体-葡萄糖复合物,顺Na+的浓度梯度进入细胞.不同物种的SGLT1具有较高的同源性.

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