Product Name	Anti-Prohibitin/PE-Cy3
Chinese Name	PE-Cy3标记的抑制素/Tumour抑制因子抗体
Alias	Mitochondrial Marker; PHB; prohibitin; PHB1; Prohibitin - Mitochondrial Marker; PHB_HUMAN.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Apoptosis  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Dog, Horse, )
Applications	IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	30kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Prohibitin
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] Function: Prohibitin inhibits DNA synthesis. It has a role in regulating proliferation. As yet it is unclear if the protein or the mRNA exhibits this effect. May play a role in regulating mitochondrial respiration activity and in aging. Subunit: Interacts with PHB2. Interacts with STOML2. Subcellular Location: Mitochondrion inner membrane. Tissue Specificity: Widely expressed in different tissues. Similarity: Belongs to the prohibitin family. Database links: Entrez Gene: 5245 Human Entrez Gene: 18673 Mouse Entrez Gene: 25344 Rat Omim: 176705 Human SwissProt: P35232 Human SwissProt: P67778 Mouse SwissProt: P67779 Rat Unigene: 514303 Human Unigene: 263862 Mouse Unigene: 29754 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Prohibitin(phb)基因是一种有效的Tumour抑制基因，广泛分布于不同种属的各种生物细胞中，它所编码的产物Prohibitin(PHB)蛋白结构保守，既存在于Mitochondrion内膜上，发挥分子伴侣作用，也存在于The nucleus内，具有负性转录调控作用，因而对细胞代谢、生长、分化、衰老以及凋亡等诸多方面发挥 着重要的调控作用，可能与某些Tumour和退行性疾病的发生有关。

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