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Product Name Anti-PHD2/PE-Cy3 Chinese Name PE-Cy3标记的脯氨酸羟化酶2抗体 Alias SM 20; Zinc finger MYND domain containing protein 6; C1ORF12; Chromosome 1 Open Reading Frame 12; ECYT 3; ECYT3; EGL 9 homolog of C. elegans 1; EGL nine (C.elegans) homolog 1; Egl nine homolog 1; Egl nine like protein 1; EGLN 1; EGLN1; HIF PH2; HIF Prolyl Hydroxylase 2; HIFP4H 2; HIFPH2; HPH 2; HPH2; Hypoxia inducible factor prolyl hydroxylase 2; ORF13; P4H2; PHD 2; PHD2; PNAS 118; PNAS 137; Prolyl Hydroxylase Domain Containing Protein 2; Rat Homolog of SM20; SM20; ZMYND6. Research Area Cell biology immunology Neurobiology Apoptosis Kinases and Phosphatases Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Pig, Cow, Rabbit, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 47kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human PHD2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
PHD2 protein catalyzes the posttranslational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. In the presence of oxygen, PHD2 converts specific prolyl residues in HIF alpha to hydroxyproline, leading to HIF alpha proteasomal degradation via the von Hippel-Lindau ubiquitylation complex. Low oxygen levels, sensed at the cellular level, cause the HIF conversion to be reduced so that HIF levels are stable. This results in increased angiogenesis as HIF1 alpha regulates the expression of many angiogenesis-related genes.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
According to PubMed:11056053, widely expressed with highest levels in skeletal muscle and heart, moderate levels in pancreas, brain (dopaminergic neurons of adult and fetal substantia nigra) and kidney, and lower levels in lung and liver. According to PubMed:12351678 widely expressed with highest levels in brain, kidney and adrenal gland. Expressed in cardiac myocytes, aortic endothelial cells and coronary artery smooth muscle. According to PubMed:12788921; expressed in adult and fetal heart, brain, liver, lung, skeletal muscle and kidney. Also expressed in placenta. Highest levels in adult heart, brain, lung and liver and fetal brain, heart spleen and skeletal muscle.
Similarity:
Contains 1 Fe2OG dioxygenase domain.
Contains 1 MYND-type zinc finger.
Database links:Entrez Gene: 54583 Human
Omim: 606425 Human
SwissProt: Q9GZT9 Human
Unigene: 444450 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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