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Product Name Anti-EEF1G/HRP Chinese Name 辣根过氧化物酶标记的延伸因子EF-1 γ抗体 Alias 2610301D06Rik; AA407312; eEF 1B gamma; EEF 1G; eEF-1B gamma; EEF1G; EF 1 gamma; EF 1G; EF-1-gamma; EF1 gamma; EF1G; EF1G_HUMAN; Elongation factor 1 gamma; Elongation factor 1-gamma; Eukaryotic translation elongation factor 1 gamma; GIG 35; GIG35; MGC103354; MGC114210; MGC144723; MGC144724; MGC94929; Pancreatic tumor related protein; PRO1608; Translation elongation factor eEF 1 gamma chain. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 50kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human EEF1G Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
EF-1 (elongation factor-1) is a multi-protein complex that is responsible for the delivery of aminoacyl-tRNAs to the ribosome. EF-1 gamma (elongation factor 1-gamma), also known as EEF1G or GIG35, is a 437 amino acid subunit of the EF-1 complex. Expressed in stomach, pancreas, brain, lung, kidney, intestine, liver and spleen, EF-1 gamma contains an N-terminal glutathione transferase domain which is thought to be involved in anchoring the complex to various cellular components. Additionally, EF-1 gamma may play a key role in the assembly of multiprotein complexes containing aminoacyl-tRNA synthetases. Increased expression of EF-1 gamma is associated with pancreatic cancer, suggesting a possible role for EF-1 gamma in the oncogenic transformation process.
Function:
Probably plays a role in anchoring the complex to other cellular components.
Subunit:
EF-1 is composed of four subunits: alpha, beta, delta, and gamma.
Tissue Specificity:
Highly expressed in pancreatic tumor tissue and to a lesser extent in normal kidney, intestine, pancreas, stomach, lung, brain, spleen and liver.
Similarity:
Contains 1 EF-1-gamma C-terminal domain.
Contains 1 GST C-terminal domain.
Contains 1 GST N-terminal domain.
Database links:
UniProtKB/Swiss-Prot: P26641.3
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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