Product Name	Anti-Bassoon/HRP
Chinese Name	辣根过氧化物酶标记的Zinc finger protein231抗体
Alias	Bassoon; BSN; KIAA0434; Neuronal double zinc finger protein; Presynaptic cytomatrix protein; Protein bassoon; Zinc finger protein 231; ZNF 231; ZNF231; Neuronal double zinc finger protein; Zinc-finger protein 231; BSN_HUMAN; ZNF 231.
Research Area	Tumour  immunology  Zinc finger protein
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	432kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BSN (2901-3000aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses. [provided by RefSeq, Jul 2008]. Function: Is thought to be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. Seems to act through binding to ERC2/CAST1. Essential in regulated neurotransmitter release from a subset of brain glutamatergic synapses. Involved in the formation of the retinal photoreceptor ribbon synapses. Subunit: Interacts with ERC2/CAST1, RIMS1 and UNC13A. Part of a complex consisting of ERC2, RIMS1 and BSN. Subcellular Location: Cytoplasm. Cell junction, synapse, synaptosome. Cytoplasm, cytoskeleton. Note=Localized to the active zone of presynaptic density. Tissue Specificity: Exclusively expressed in brain. Post-translational modifications: Myristoylated. The N-terminal myristoylation is not sufficient for presynaptic localization. Database links: Entrez Gene: 8927 Human Entrez Gene: 12217 Mouse Entrez Gene: 29138 Rat Omim: 604020 Human SwissProt: O43161 Human SwissProt: Q9UPA5 Human SwissProt: O88737 Mouse SwissProt: O88778 Rat Unigene: 194684 Human Unigene: 20425 Mouse Unigene: 29999 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Zinc finger protein是80年代中期发现的一类DNABinding protein，在真核生物中,Zinc finger protein可能是最大的一类DNABinding protein，并且由Zinc finger protein调控基因表达是发育和其他过程的一个非常普遍的现象。在最近的几年中，发现某些Zinc finger protein对肌肉的发育具有重要的调节作用。

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