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Product Name Anti-Cyclooxygenase 1/HRP Chinese Name 辣根过氧化物酶标记的前列腺素氧化环化酶1抗体 Alias Cyclooxygenase-1; COX-1; COX 1; COX1; Cyclooxygenase1; Prostaglandin-endoperoxide synthase-1; prostaglandin-endoperoxide synthase 1; PTGS-1; Prostaglandin G/H synthase 1 precursor; prostaglandin G/H synthase 1 isoform 1 precursor; Prostaglandin H2 synthase 1; PGH synthase 1; PGHS-1; PHS 1; PGH1_HUMAN; PTGS1; Prostaglandin G/H synthase 1 precursor. Research Area Tumour Cardiovascular immunology Signal transduction Synthesis and Degradation Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Pig, Cow, Sheep, ) Applications WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 63kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Cyclooxygenase 1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012].
Function:
May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells.
Subunit:
Homodimer.
Subcellular Location:
Microsome membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein.
Similarity:
Belongs to the prostaglandin G/H synthase family.
Contains 1 EGF-like domain.
Database links:Entrez Gene: 5742 Human
Entrez Gene: 19224 Mouse
Omim: 176805 Human
SwissProt: P23219 Human
SwissProt: P22437 Mouse
Unigene: 201978 Human
Unigene: 275434 Mouse
Unigene: 44404 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Synthesis and Degradation(Synthesis and Degradation)
COX1 前列腺素氧化环化酶-是前列腺素合成的关键酶之一,为诱导性酶,他参与细胞对生长因子、Tumour促进因子和cell factor的反应,这些因子均能诱导COX1表达,它也参与前列腺素的合成。
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