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Product Name Anti-TRAP1/HSP75/HRP Chinese Name 辣根过氧化物酶标记的热休克蛋白75抗体 Alias TRAP1; TRAP-1; Heat shock protein 75; Heat shock protein 75 kDa mitochondrial; HSP 75; HSP 90L; HSP75; HSP90L; TNF receptor associated protein 1; TNFR associated protein 1; TRAP 1; Tumor necrosis factor receptor associated protein; Tumor necrosis factor type 1 receptor associated protein; TRAP1_HUMAN. Research Area Tumour Cell biology immunology Signal transduction Apoptosis transcriptional regulatory factor Mitochondrion Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 74kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human HSP75 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Function:
Chaperone that expresses an ATPase activity.
Subunit:
Binds to the intracellular domain of tumor necrosis factor type 1 receptor. Binds to RB1.
Subcellular Location:
Mitochondrion.
Tissue Specificity:
Found in skeletal muscle, liver, heart, brain, kidney, pancreas, lung and placenta.
Similarity:
Belongs to the heat shock protein 90 family.
Database links:Entrez Gene: 10131 Human
Entrez Gene: 68015 Mouse
Entrez Gene: 416666 Chicken
Omim: 606219 Human
SwissProt: Q12931 Human
SwissProt: Q9CQN1 Mouse
Unigene: 30345 Human
Unigene: 123366 Mouse
Unigene: 144695 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
信号传导(Signaling Intermediates)
HSP75/TRAP-1与TNF受体发生相互作用,可产生促进TNF的Signal transduction。
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