Rabbit Anti-Cathepsin B/HRP Conjugated antibody
Amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; CB; Cathepsin B1; CathepsinB; CPSB; CTSB; Cysteine protease; Preprocathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; CATB_HUMAN.
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Product Name Anti-Cathepsin B/HRP Chinese Name 辣根过氧化物酶标记的组织蛋白酶B抗体 Alias Amyloid precursor protein secretase; APP secretase; APPS; Cathepsin B; CB; Cathepsin B1; CathepsinB; CPSB; CTSB; Cysteine protease; Preprocathepsin B; Cathepsin B heavy chain; Cathepsin B light chain; CATB_HUMAN. Research Area Tumour immunology Synthesis and Degradation Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, Rat, Applications WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 23/28/37kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Cathepsin B heavy chain Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Function:
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.
Subunit:
Dimer of a heavy chain and a light chain cross-linked by a disulfide bond. Interacts with SRPX2.
Subcellular Location:
Lysosome. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Similarity:
Belongs to the peptidase C1 family.
Database links:Entrez Gene: 1508 Human
Entrez Gene: 13030 Mouse
Omim: 116810 Human
SwissProt: P07858 Human
SwissProt: P10605 Mouse
Unigene: 520898 Human
Unigene: 236553 Mouse
Unigene: 472420 Mouse
Unigene: 100909 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Synthesis and Degradation（Synthesis and Degradation）
组织蛋白酶B(CB) 参与Tumour的侵袭转移过程。可促进Tumour血管的增生，增强Tumour细胞的运动能力.组织蛋白酶B转录以及表达水平的高低与Tumour预后呈正相关。
cathepsin B属于半胱氨酸蛋白酶,与人体的多种生理、病理过程密切相关.组织蛋白酶B (cathepsin B,CB)主要存在于溶酶体中, 发挥其生理状态下的蛋白水解作用.但在某些特定条件下, CB在胞外间质中有时也可以检测到.
目前，有学者将CB用于阿尔茨海默病（AD）方面的研究。
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