Product Name	Anti-Profilin 2/HRP
Chinese Name	辣根过氧化物酶标记的前纤维蛋白2抗体
Alias	D3S1319E; PFL; PFN 2; PFN2; Profilin II; Profilin-2; Profilin 2; Profilin2; ProfilinII; Profilin II; Profilin-II; PFN2; PROF2_HUMAN
Research Area	Cell biology  Neurobiology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Chicken, Pig, Cow, )
Applications	ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	16kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Profilin 2
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Profilin 2 is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals by binding to actin (1:1 ratio) and so affecting the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Highly expressed in skeletal muscle, kidney and brain and less strongly in placenta, heart, liver and lung. Function: Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. Subunit: Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. Subcellular Location: Cytoplasm, cytoskeleton. Tissue Specificity: Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. Similarity: Belongs to the profilin family. Database links: Entrez Gene: 5217 Human Entrez Gene: 18645 Mouse Entrez Gene: 81531 Rat Omim: 176590 Human SwissProt: P35080 Human SwissProt: Q9JJV2 Mouse SwissProt: Q9EPC6 Rat Unigene: 91747 Human Unigene: 271744 Mouse Unigene: 203100 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 前纤维蛋白(profilin)是一种低分子量的肌动蛋白Binding protein, 前纤维蛋白除了能与肌动蛋白结合之外,在分子间相互作用的复杂网络中还起到一个控制中心的作用。

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