Product Name	Anti-CYP46/HRP
Chinese Name	辣根过氧化物酶标记的胆固醇24S－羟化酶
Alias	Cholesterol 24-hydroxylase; CP46; CYP46; CP46A_HUMAN; cytochrome P450 family 46.
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  The new supersedes the old
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:100-1000 IHC-P=1:50-200 IHC-F=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	57kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CYP46
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The Cyp46 gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed exclusively in the brain, where it converts cholesterol to 24S-hydroxycholesterol by adding a hydroxyl group to cholesterol, producing a product that is more soluble than cholesterol and able to be exported from the brain. Cyp46 is also known as 24S-cholesterol hydroxylase. Function: Involved in the turnover of cholesterol. It converts cholesterol into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. Has also activity with xenobiotic compounds, such as clotrimazole. Subcellular Location: Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. Tissue Specificity: Expressed in brain. The mRNA was broadly distributed with higher levels in gray matter zones and lower levels in regions rich in white matter. Not detected in fetal sample but its expression increases linearly with age. Similarity: Belongs to the cytochrome P450 family. Database links: Entrez Gene: 10858 Human Entrez Gene: 13116 Mouse Entrez Gene: 362782 Rat Omim: 604087 Human SwissProt: Q9Y6A2 Human SwissProt: Q9WVK8 Mouse Unigene: 25121 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 经研究发现CYP46和APOE-4基因都产生变异的人,患老年性痴呆症的风险比正常人高将近10倍，尤其CYP46蛋白控制产生的一种酶,能帮助大脑分解多余的胆固醇;而APOE-4的基因在人体胆固醇的运输过程中起到作用。这说明胆固醇和β-淀粉蛋白的积聚之间也许存在某种关联,人体胆固醇The new supersedes the old的不足,也可能是导致老年性痴呆症的“罪魁祸首”。

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