Product Name	Anti-Acetylated Lysine/Gold
Chinese Name	胶体金标记的乙酰基赖氨酸/乙酰化赖氨酸抗体
Alias	Ac-lysine; Ac lysine; Ac-K; Ac K; Ac-Lys; Ac Lys; acetyl-Lysine; acetyl Lysine; acetyl-Lys; acetyl Lys.
Product Type	Small molecule anti
Research Area	Cell biology  immunology  Epigenetics
Immunogen Species	Mouse
Clonality	Monoclonal
Clone NO.	10C12
React Species
Applications	IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Form	Lyophilized or Liquid
Concentration	0.4mg/ml
immunogen	BSA conjugated Acetylated Lysine
Lsotype	IgG
Purification	affinity purified by Protein G
Storage Buffer	0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
Storage	Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
Product Detail	background: In the nucleus, DNA is tightly packed into nucleosomes generating an environment which is highly repressive towards DNA processes such as transcription. Acetylation of lysine residues within proteins has emerged as an important mechanism used by cells to overcome this repression. The acetylation of non-histone proteins such as transcription factors, as well as histones appears to be involved in this process. Acetylation may result in structural transitions as well as specific signaling within discrete chromatin domains. The role of acetylation in intracellular signaling has been inferred from the binding of acetylated peptides by the conserved bromodomain. Furthermore, recent findings suggest that bromodomain/acetylated-lysine recognition can serve as a regulatory mechanism in protein-protein interactions in numerous cellular processes such as chromatin remodeling and transcriptional activation. The reversible lysine acetylation of histones and non-histone proteins plays a vital role in the regulation of many cellular processes including chromatin dynamics and transcription, gene silencing, cell cycle progression, apoptosis, differentiation, DNA replication, DNA repair, nuclear import, and neuronal repression. More than 20 acetyltransferases and 18 deacetylases have been identified so far, but the mechanistic details of substrate selection and site specificity of these enzymes remain unclear. Over 40 transcription factors and 30 other nuclear, cytoplasmic, bacterial, and viral proteins have been shown to be acetylated in vivo. Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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