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Product Name Anti-PPAR delta/Gold Chinese Name 胶体金标记的D型-过氧化酶活化增生受体单克隆抗体 Alias FAAR; MGC3931; NR1C2; NUC1; NUCI; NUCII; Nuclear hormone receptor 1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferative activated receptor delta; Peroxisome proliferator-activated receptor beta (PPAR-beta); Peroxisome proliferator-activated receptor beta; Peroxisome proliferator-activated receptor delta; PPAR beta; PPAR-beta; PPAR-delta; PPAR-? PPARB; PPARD; PPARD_HUMAN. Research Area Cardiovascular immunology Immunogen Species Mouse Clonality Monoclonal Clone NO. 4H10 React Species (predicted: Human, Mouse, Rat, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 48kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen Recombinant human PPAR delta Protein Lsotype IgG Purification affinity purified by Protein G Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to a promoter element in the gene for acyl-CoA oxidase and activates its transcription. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Heterodimer with the retinoid X receptor. Subcellular located at nuclear Tissue specificity: Heart, adrenal and intestine. Belongs to the nuclear hormone receptor family. NR1 subfamily. It Contains 1 nuclear receptor DNA-binding domain.
Function:
Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand.
Subcellular Location:
Nucleus.
Tissue Specificity:
Ubiquitous with maximal levels in placenta and skeletal muscle.
Similarity:
Belongs to the nuclear hormone receptor family. NR1 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
Database links:Entrez Gene: 5467 Human
Entrez Gene: 19015 Mouse
Omim: 600409 Human
SwissProt: Q03181 Human
SwissProt: P35396 Mouse
Unigene: 696032 Human
Unigene: 328914 Mouse
Unigene: 96181 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
类固醇受体(Steroid Receptors)
研究人员指出该分子的功能,极可能就是阻断Cardiovascular免疫发炎反应的讯号传递过程。PPAR-delta基因是控制肌肉发展的重要基因,在增加老鼠耐力的同时还能帮助它燃烧掉脂肪,研究人员发现,对于与The new supersedes the old有关的各项疾病,从心脏病到肥胖症都有启发性的意义,他可以阻止脂肪沉淀在动脉壁上,进而防止动脉硬化症的发生,该蛋白参与脂肪代谢、肥胖、Diabetes、动脉硬化和癌症的发病。
在动脉硬化现象发生的早期,免疫细胞会促使血管慢性的发炎,因而造成血管不断地吸收和输送脂肪,进而导致脂肪的堆积与血管硬化,而PPAR-delta就像警卫分子一样,时时降低发炎反应和抑制动脉硬化斑的形成,因此该分子应该是相关药物研发,相当值得切入的目标。
研究人员认为,这个发现将给药厂研发治疗Cardiovascular疾病的新药提供新的线索。
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