TEL: +86 571 56623320 EMAIL: [email protected]
Product Name Anti-ZBTB4/Gold Chinese Name 胶体金标记的Zinc finger protein903抗体 Alias KAISO-L1; KAISO-like zinc finger protein 1; KIAA1538; ZBTB4; ZBTB4_HUMAN; Zinc finger and BTB domain containing 4; Zinc finger and BTB domain-containing protein 4; ZNF903. Research Area Cell biology transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 105kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human ZBTB4/ZNF903 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZBTB4 (zinc finger and BTB domain containing 4), also known as KAISO-L1 (KAISO-like zinc finger protein 1), is a 1,013 amino acid nuclear protein that is involved in transcriptional regulation. ZBTB4 contains one BTB (POZ) domain, six C2H2-type zinc fingers and is phosphorylated and downregulated by HIPK2. The gene encoding ZBTB4 maps to human chromosome 17, which comprises over 2.5% of the human genome and encodes over 1,200 genes.
Function:
May be involved in transcriptional regulation.
Subunit:
Interacts with HIPK2.
Subcellular Location:
Nucleus.
Post-translational modifications:
Phosphorylated by HIPK2. This phosphorylation reduces stability and triggers ZBTB4 protein degradation in response to DNA damage.
Similarity:
Contains 1 BTB (POZ) domain.
Contains 6 C2H2-type zinc fingers.
Database links:Entrez Gene: 57659 Human
Entrez Gene: 75580 Mouse
Omim: 612308 Human
SwissProt: Q9P1Z0 Human
Unigene: 35096 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Scan Wechat Qrcode
Scan Whatsapp Qrcode