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Product Name Anti-ZBT24/Gold Chinese Name 胶体金标记的Zinc finger protein450抗体 Alias ZBTB24; BIF1; ICF2; OTTHUMP00000016968; POZ (BTB) and AT hook containing zinc finger 2; ZBT24_HUMAN; Zbtb24; Zinc finger and BTB domain-containing protein 24; Zinc finger protein 450; ZNF45; PATZ2. Research Area Cell biology Signal transduction Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 78kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human ZBT24/ZNF45 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
This gene encodes a protein similar to a protein in rodents which is induced by bone morphogenic protein 2 in vitro. [provided by RefSeq, Aug 2011]
Function:
May be involved in BMP2-induced transcription.
Subcellular Location:
Nucleus.
Tissue Specificity:
Widely expressed, with highest levels in naive B-cells.
DISEASE:
Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2) [MIM:614069]: A rare disorder characterized by a variable immunodeficiency resulting in recurrent infections, facial anomalies, and branching of chromosomes 1, 9, and 16. Other variable symptoms include growth retardation, failure to thrive, and psychomotor retardation. Laboratory studies show limited hypomethylation of DNA in a small fraction of the genome in some, but not all, patients. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family.
Contains 1 A.T hook DNA-binding domain.
Contains 1 BTB (POZ) domain.
Contains 8 C2H2-type zinc fingers.
Database links:Entrez Gene: 9841 Human
Omim: 614064 Human
SwissProt: O43167 Human
Unigene: 409876 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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