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Product Name Anti-TP-5/Thymopentin/Gold Chinese Name 胶体金标记的胸腺五肽抗体 Research Area Tumour Cell biology immunology Diabetes lymphocyte t-lymphocyte Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human TP-5/Thymopentin Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Sequence:: H-Arg-Lys-Asp-Val-Tyr-OH
MW: 679.8
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
胸腺五肽的作用之一是诱导TCell differentiation。它可选择性地诱导Thy-1-的前胸腺细胞转化为Thy-1+的T细胞。其TCell differentiation作用由胞内cAMP水平升高介导。胸腺五肽的另一基本作用是对成熟外周血T细胞的特异受体结合,使胞内cAMP水平上升,从而诱发一系列胞内反应,这也是它免疫调节功能的基础。在正常机体状态下胸腺五肽显现免疫刺激作用,能显著增高脾lymphocyte的E玫瑰花结形成率及转化率,对免疫应答的初次或再次反应的不同阶段都有增强作用,能增多IgM类型和IgG或IgA类型的抗体形成细胞。胸腺五肽还可增强巨噬细胞的吞噬功能,增加多形核嗜中性白细胞的酶和吞噬功能,升高循环抗体含量,增强红细胞免疫功能。胸腺五肽能活化CD4和CD8阳性细胞,使专一的Tc细胞寿命维持更长时间,同时也可活化Th细胞,诱导Ts细胞的功能。胸腺五肽的抗感染力和治疗作用与它增进TC细胞活性相关。在抗感染免疫中适量胸腺五肽可明显增加Interferon的产生。诱导和促进TCell differentiation成熟;调节Tlymphocyte亚群比例使CD4/CD8趋于正常 ;增强巨噬细胞吞噬功能 ;增强红细胞免疫功能 ;提高Natural killer cells的活力 ;提高白介素-2的产生水平与受体表达水平;增强外周血单核细胞γInterferon的产生 ;增强血清中SOD活性。
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