Product Name	Anti-GPR116/Gold
Chinese Name	胶体金标记的G protein-coupled receptor116抗体
Alias	DKFZp564O1923; FLJ90640; G protein coupled receptor 116; G protein coupled receptor 116; GP116_HUMAN; GPR116; Ig Hepta homolog; KIAA0758; KIAA0758; KPG_001; OTTHUMP00000016557; Probable G protein coupled receptor 116; Probable G-protein coupled receptor 116； GPCR GPR116.
Research Area	Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Rabbit, )
Applications	IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	147kDa
Form	Lyophilized or Liquid
Concentration	0.4mg/ml
immunogen	KLH conjugated synthetic peptide derived from human G protein coupled receptor 116
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
Storage	Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
Product Detail	background: G protein-coupled receptors (GPRs), also known as seven transmembrane receptors, heptahelical receptors or 7TM receptors, comprise a superfamily of proteins that play a role in many different stimulus-response pathways. G protein coupled receptors translate extracellular signals into intracellular signals (G protein activation) and they respond to a variety of signaling molecules, such as hormones and neurotransmitters. GPR116 (G protein-coupled receptor 116) is a 1,346 amino acid multi-pass membrane protein that contains one SEA domain, one GPS domain and three Ig-like domains and belongs to the GPR family. Existing as a dilsulfide-liked homodimer at the cell surface, GPR116 exists as multiple alternatively spliced isoforms and is thought to play a role in regulating and maintaining proper acid-base balance throughout the cell. Function: May have a role in the regulation of acid-base balance. Subunit: Exists as disulfide-linked dimers at the cell surface Subcellular Location: Cell membrane; Multi-pass membrane protein Post-translational modifications: Proteolytically cleaved into 2 highly conserved sites: one in the SEA domain and the other in the stalk domain region preceding the first transmembrane. The later 2 subunits, the extracellular subunit and the seven-transmembrane subunit, remain tightly associated and non-covalently linked. Similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. Contains 1 GPS domain. Contains 3 Ig-like (immunoglobulin-like) domains. Contains 1 SEA domain. Database links: UniProtKB/Swiss-Prot: Q8IZF2.3 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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