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Product Name Anti-Adenylate Kinase 1/Gold Chinese Name 胶体金标记的腺苷酸激酶-1抗体 Alias Adenylate kinase isoenzyme 1; Adenylate kinase soluble; AK 1; AK1; AK-1; ATP AMP transphosphorylase; Myokinase; KAD1_HUMAN; ATP-AMP transphosphorylase 1. Research Area Tumour Cardiovascular Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, Goat, Monkey, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 21kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human Adenylate Kinase 1 (131-194aa) Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme. [provided by RefSeq, Jul 2008].
Function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth.
Subunit:
Monomer.
Subcellular Location:
Cytoplasm.
DISEASE:
Defects in AK1 are the cause of hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631].
Similarity:
Belongs to the adenylate kinase family.
Database links:Entrez Gene: 203 Human
Entrez Gene: 11636 Mouse
Omim: 103000 Human
SwissProt: P00568 Human
SwissProt: Q9R0Y5 Mouse
Unigene: 175473 Human
Unigene: 29189 Mouse
Unigene: 79537 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
AK1存在于人类红细胞上及某些组织中的具有遗传多态性的同工酶, 腺苷酸激酶催化 ATP,AMP 和 ADP 的转化,它是维持各种腺苷酸平衡的关键酶。因此,腺苷酸激酶就成为调控腺苷酸库大小的靶标分子。
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