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Product Name Anti-Visfatin/Gold Chinese Name 胶体金标记的内脂素/内脏脂肪素/前B细胞克隆增强因子1抗体 Alias pre-B-cell colony enhancing factor 1 transcript variant 2; PBEF1 protein; 1110035O14Rik; AI314458; AI480535; NAmPRTase; Pbef; Pbef1; PBEF1; NAMPT_HUMAN. Research Area Neurobiology Diabetes Endocrinopathy Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Monkey, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 55kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human Visfatin-2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10. [provided by RefSeq, Feb 2011].
Function:
Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway.
Subunit:
Homodimer.
Subcellular Location:
Cytoplasm. Nucleus.
Tissue Specificity:
Expressed in large amounts in bone marrow, liver tissue, and muscle. Also present in heart, placenta, lung, and kidney tissues.
Similarity:
Belongs to the NAPRTase family.
Database links:Entrez Gene: 10135 Human
Entrez Gene: 59027 Mouse
Omim: 608764 Human
SwissProt: P43490 Human
SwissProt: Q99KQ4 Mouse
Unigene: 489615 Human
Unigene: 202727 Mouse
Unigene: 203508 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
一种新的脂肪因子-visfatin (前B细胞克隆增强因子-2)是新近发现的主要由人和小鼠内脏脂肪组织分泌的一种脂肪cell factor,其结构与pre-B细胞集落增强因子相似.它能够发挥类似胰岛素的作用,与Ⅱ型Diabetes相关联,降低血糖,促进糖摄取,可结合并活化胰岛素受体,激活胰岛素信号通路.内脏脂肪因子-Visfatin与肥胖密切相关并能够促进脂肪细胞的分化,还能促进血管平滑肌细胞成熟.
Visfatin的表达受炎症反应因子和多种激素的调节.PBEF-1可能是联系机体糖脂代谢的重要分子,它的发现可为揭示Diabetes与肥胖的发生发展机制提供新的研究思路,为代谢综合征的治疗提供新方案.
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