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Product Name Anti-Neurogenin 3/Gold Chinese Name 胶体金标记的神经元素3抗体 Alias NGN3; neurogenin 3; Neurog3; Neurogenin3; Neurogenin-3; ATH4B; Atoh5; Math4B; NEUROG3; ngn3; OTTHUMP00000019730; Protein atonal homolog 5. Research Area Cell biology Neurobiology Signal transduction transcriptional regulatory factor Immunogen Species Rabbit Clonality Polyclonal React Species Human, Mouse, (predicted: Rat, Dog, Cow, Sheep, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 23kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human NGN3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Neurogenin-3 (NEUROG3) is expressed in endocrine progenitor cells and is required for endocrine cell development in the pancreas and intestine (Wang et al., 2006 [PubMed 16855267]). It belongs to a family of basic helix-loop-helix transcription factors involved in the determination of neural precursor cells in the neuroectoderm.
Function:
Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types.
Subcellular Location:
Nucleus.
DISEASE:
Defects in NEUROG3 are the cause of diarrhea type 4 (DIAR4) [MIM:610370]. DIAR4 is a characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells.
Similarity:
Contains 1 basic helix-loop-helix (bHLH) domain.
Database links:Entrez Gene: 50674 Human
Entrez Gene: 11925 Mouse
Omim: 604882 Human
SwissProt: Q9Y4Z2 Human
SwissProt: P70661 Mouse
Unigene: 532682 Human
Unigene: 57236 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
Neurobiology相关蛋白(Neurobiology)
Ngn3属于bHLH家族蛋白,是胰腺发育过程中短暂表达的蛋白,可能是胰腺内分泌细胞系的定向因子,一般在成熟胰岛中不存在。
Ngn3的表达会导致胰腺内分泌细胞数的增加外分泌细胞数的减少。因而胰岛β细胞并不是完全靠Stem cells分化产生,主要是通过已分化胰岛β细胞的分裂增殖。
但近年来,有学者认为:Ngn3虽在胰腺发育中短暂表达,但是否存在使胰岛Stem cells或前体细胞自我更新的能力尚未明确定论。
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