Product Name	Anti-CDK3/Gold
Chinese Name	胶体金标记的周期素依赖性激酶3抗体
Alias	Cdk 3; Cell division kinase 3; Cell division protein kinase 3; Cyclin dependent kinase 3; p36; Cdk3; CDK3_HUMAN; CDKN3; Cell division protein kinase 3; Cyclin dependent kinase 3; Cyclin-dependent kinase 3; OTTHUMP00000206828; p36.
Research Area	Cell biology  Signal transduction  Cyclin  Kinases and Phosphatases
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Guinea Pig, )
Applications	IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	34kDa
Form	Lyophilized or Liquid
Concentration	0.4mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CDK3
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
Storage	Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
Product Detail	background: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008] Function: Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Subunit: Interacts with CABLES1 and CABLES2. Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation. Tissue Specificity: Expressed in cancer cell lines and glioblastoma tissue. Similarity: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Contains 1 protein kinase domain. Database links: Entrez Gene: 1018 Human Omim: 123828 Human SwissProt: Q00526 Human Unigene: 706766 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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