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Product Name Anti-Contactin 6/Gold Chinese Name 胶体金标记的神经细胞NB3特定蛋白抗体 Alias CNTN 6; CNTN6; CNTN6_HUMAN; Contactin 6 precursor; Contactin-6; Contactin6; hNB 3; hNB-3; hNB3; MGC133256; NB 3; NB3; Neural adhesion molecule; Neural recognition molecule NB 3; Neural recognition molecule NB-3. Research Area Neurobiology The cell membrane蛋白 Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 109kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human NB3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
Contactin 6 is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein which functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system.
Function:
Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
Subunit:
Belongs to the immunoglobulin superfamily. Contactin family. Contains 4 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor (By similarity).
Tissue Specificity:
Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
Similarity:
Belongs to the immunoglobulin superfamily. Contactin family.
Contains 4 fibronectin type-III domains.
Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Database links:Entrez Gene: 27255 Human
Entrez Gene: 53870 Mouse
Omim: 607220 Human
SwissProt: Q9UQ52 Human
SwissProt: Q9JMB8 Mouse
Unigene: 387300 Human
Unigene: 321671 Mouse
Unigene: 10644 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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