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Product Name Anti-TNFAIP1/Gold Chinese Name 胶体金标记的Tumour坏死因子α诱导蛋白1抗体 Alias tumor necrosis factor, alpha-induced protein 1-like; Tumor necrosis factor-alpha-induced protein 1; Tumor necrosis factor alpha induced protein 1 (endothelial); BACD2_HUMAN; BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2; BTB/POZ domain-containing protein TNFAIP1; endothelial; hBACURD2; Protein B12; tnfaip1; Tumor necrosis factor alpha induced protein 1; TNF-IP 1; TNF-IP-1; TNF-IP1. Research Area Tumour Cell biology immunology Neurobiology Apoptosis Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, ) Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 35kDa Form Lyophilized or Liquid Concentration 0.4mg/ml immunogen KLH conjugated synthetic peptide derived from human TNFAIP1 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300. Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles. Product Detail background:
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. Studies of a similar gene in mouse suggest that the expression of this gene is developmentally regulated in a tissue-specific manner. [provided by RefSeq, Jul 2008].
Function:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(BACURD2) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity.
Subcellular Location:
Cytoplasm. Nucleus. Endosome. Colocalizes with RHOB in endosomes.
Post-translational modifications:
Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA.
Similarity:
Belongs to the BACURD family.
Contains 1 BTB (POZ) domain.
Database links:Entrez Gene: 7126 Human
Entrez Gene: 21927 Mouse
Omim: 191161 Human
SwissProt: Q13829 Human
SwissProt: O70479 Mouse
Unigene: 76090 Human
Unigene: 386774 Mouse
Unigene: 18199 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
TNFAIP1 protein是第一个被鉴定受Tumour坏死因子α诱导的蛋白,实验证明TNFAIP1 蛋白可能参与DNA复制、合成、Apoptosis以及人类的各种疾病等重要生理过程,但还有一些功能不清。
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