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Rabbit Anti-MIP4/Gold Conjugated antibody
Rabbit Anti-MIP4/Gold Conjugated antibody
Macrophage Inflammatory Protein 4; Alternative macrophage activation associated CC chemokine 1; Alternative macrophage activation-associated CC chemokine 1; AMAC-1; AMAC1; C-C motif chemokine 18; CC chemokine PARC; CCL18; CCL18(1-68); CCL18(3-69); CCL18(4
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Product Name Anti-MIP4/Gold
Chinese Name 胶体金标记的巨噬细胞炎症蛋白18抗体
Alias Macrophage Inflammatory Protein 4; Alternative macrophage activation associated CC chemokine 1; Alternative macrophage activation-associated CC chemokine 1; AMAC-1; AMAC1; C-C motif chemokine 18; CC chemokine PARC; CCL18; CCL18(1-68); CCL18(3-69); CCL18(4-69); CCL18_HUMAN; CKb7; DC-CK1; DCCK1; Dendritic cell chemokine 1; Macrophage inflammatory protein 4; MIP-4; MIP4; PARC; Pulmonary and activation regulated chemokine; Pulmonary and activation-regulated chemokine; SCYA18; Small inducible cytokine A18; Small-inducible cytokine A18.  
Research Area Cell biology  immunology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Mouse,  (predicted: Human, )
Applications IEM=1:20-200 ICA=1:20-200 ChIP=1:20-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 8kDa
Form Lyophilized or Liquid
Concentration 0.4mg/ml
immunogen KLH conjugated synthetic peptide derived from human MIP4
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.02M TBS(pH8.2) with 1% BSA, 0.03% Proclin300.
Storage Store at 2-8 ºC for 3-6 months. Avoid repeated freeze/thaw cycles.
Product Detail background:
This chemotactic factor that attracts lymphocytes but not monocytes or granulocytes may be involved in B cell migration into B cell follicles in lymph nodes. It attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T cells, CD4+ and CD8+ T cells and thus may play a role in both humoral and cell-mediated immunity responses. It is expressed at high levels in lung, lymph nodes, placenta, and bone marrow, not expressed by peripheral blood monocytes, and a monocyte-to-macrophage differentiation is a prerequisite for expression. Specifically induced in macrophages by IL4, IL13, and IL10, it belongs to the intercrine beta (chemokine CC) family.

Function:
Chemotactic factor that attracts lymphocytes but not monocytes or granulocytes. May be involved in B-cell migration into B-cell follicles in lymph nodes. Attracts naive T-lymphocytes toward dendritic cells and activated macrophages in lymph nodes, has chemotactic activity for naive T-cells, CD4+ and CD8+ T-cells and thus may play a role in both humoral and cell-mediated immunity responses.

Subcellular Location:
Secreted.

Tissue Specificity:
Expressed at high levels in lung, lymph nodes, placenta, bone marrow, dendritic cells present in germinal centers and T-cell areas of secondary lymphoid organs and macrophages derived from peripheral blood monocytes. Not expressed by peripheral blood monocytes and a monocyte-to-macrophage differentiation is a prerequisite for expression. Expressed in synovial fluids from patients with rheumatoid and septic arthritis and in ovarian carcinoma ascitic fluid.

Similarity:
Belongs to the intercrine beta (chemokine CC) family.

Database links:

Entrez Gene: 6362 Human

Omim: 603757 Human

SwissProt: P55774 Human

Unigene: 143961 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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