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Product Name Anti-NCX3/FITC Chinese Name FITC标记的钠钙Exchange protein3抗体 Alias AW742262; MGC90626; Na(+)/Ca(2+)-exchange protein 3; Na+/Ca2+ exchange protein 3; Na+/Ca2+ exchanger 3; NAC3_HUMAN; NCX3; SCL8A3; Sodium calcium exchanger form 3; Sodium/calcium exchanger 3; Sodium/calcium exchanger SLC8A3; Solute carrier family 8 sodium calcium exchanger member 3. Research Area Tumour Neurobiology Signal transduction The new supersedes the old Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, ) Applications IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 100kDa Cellular localization The cell membrane Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human NCX3 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
SLC8A3 is a member of the sodium/calcium exchanger integral membrane protein family. Three mammalian isoforms in family 8 have been identified. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner.
Function:
Rapidly transports Ca(2+) during excitation-contraction coupling. Ca(2+) is extruded from the cell during relaxation so as to prevent overloading of intracellular stores (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein.
Tissue Specificity:
Isoform 2 is expressed in brain and skeletal muscle. Isoform 3 is expressed in excitable cells of brain, retina and skeletal muscle. Isoform 4 is expressed in skeletal muscle.
Similarity:
Belongs to the sodium/potassium/calcium exchangerv family. SLC8 subfamily.
Contains 2 Calx-beta domains.
Database links:Entrez Gene: 6547 Human
Entrez Gene: 110893 Mouse
Omim: 607991 Human
SwissProt: P57103 Human
Unigene: 337696 Human
Unigene: 443748 Mouse
Unigene: 67030 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
钠钙Exchange protein又称钠钙交换体,有三种同分异构体,即NCX1、NCX2和NCX3。3型Na-CaExchange protein-NCX3, 主要在脑组织表达,分布与胞浆及胞膜。
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