Product Name	Anti-BCMA/FITC
Chinese Name	FITC标记的Blymphocyte成熟因子抗体
Alias	B cell maturation antigen; B Cell Maturation Factor; B cell maturation protein; BCM; BCMA; CD269; CD269 antigen; TNFRSF17; Tumor Necrosis Factor Receptor Member 17; Tumor necrosis factor receptor superfamily member 17; TNR17_HUMAN.
Research Area	Tumour  Cell biology  immunology  transcriptional regulatory factor  b-lymphocyte
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, )
Applications	Flow-Cyt=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	20kDa
Cellular localization	The cell membrane
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BCMA
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation. [provided by RefSeq]. Function: Receptor for TNFSF13B/BLyS/BAFF and TNFSF13/APRIL. Promotes B-cell survival and plays a role in the regulation of humoral immunity. Activates NF-kappa-B and JNK. Subunit: Associates with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Subcellular Location: Cell membrane; Single-pass type III membrane protein. Endomembrane system; Single-pass type III membrane protein. Tissue Specificity: Expressed in mature B-cells, but not in T-cells or monocytes. DISEASE: Note=A chromosomal aberration involving TNFRSF17 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with IL2. Similarity: Contains 1 TNFR-Cys repeat. Database links: Entrez Gene: 608 Human Omim: 109545 Human SwissProt: Q02223 Human Unigene: 2556 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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