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Rabbit Anti-LMF1/Cy7 Conjugated antibody
Rabbit Anti-LMF1/Cy7 Conjugated antibody
AW822050; C16orf26; cld; FLJ12681; FLJ22302; HMFN1876; JFP11; Lipase maturation factor 1; LMF1; LMF1_HUMAN; RGD1310180; TMEM112; TMEM112A; Transmembrane protein 112.
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Details

Product Name Anti-LMF1/Cy7
Chinese Name Cy7标记的脂肪酶成熟因子1抗体
Alias AW822050; C16orf26; cld; FLJ12681; FLJ22302; HMFN1876; JFP11; Lipase maturation factor 1; LMF1; LMF1_HUMAN; RGD1310180; TMEM112; TMEM112A; Transmembrane protein 112.  
Research Area Tumour  Cell biology  immunology  The new supersedes the old  
Immunogen Species Rabbit
Clonality Polyclonal
React Species (predicted: Human, )
Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 65kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human LMF1
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The protein encoded by this gene resides in the endoplasmic reticulum, and is involved in the maturation and transport of lipoprotein lipase through the secretory pathway. Mutations in this gene are associated with combined lipase deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2010]

Function:
Involved in the maturation of specific proteins in the endoplasmic reticulum. Required for maturation and transport of active lipoprotein lipase (LPL) through the secretory pathway.

Subcellular Location:
Endoplasmic reticulum membrane.

DISEASE:
Defects in LMF1 are the cause of combined lipase deficiency (CLD) [MIM:246650]. CLD is characterized by repeated episodes of pancreatitis, tuberous xanthomas and lipodystrophy and is caused by deficiency of both lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL).

Similarity:
Belongs to the lipase maturation factor family.

Database links:

Entrez Gene: 64788 Human

Omim: 611761 Human

SwissProt: Q96S06 Human

Unigene: 71912 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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