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Rabbit Anti-ORC6/Cy7 Conjugated antibody
Rabbit Anti-ORC6/Cy7 Conjugated antibody
ORC6L; origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like (yeast).
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  • NO.:SL18027R-Cy7
    Clonality:Polyclonal
    Immunogen Species:Rabbit
    React Species:Rat,(predicted: Human,Mouse,Dog,Horse,Rabbit,)
    concentration:1mg/ml
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Details

Product Name Anti-ORC6/Cy7
Chinese Name Cy7标记的ORC6蛋白抗体
Alias ORC6L; origin recognition complex subunit 6; origin recognition complex subunit 6 homolog like (yeast).  
Research Area Cell biology  
Immunogen Species Rabbit
Clonality Polyclonal
React Species Rat,  (predicted: Human, Mouse, Dog, Horse, Rabbit, )
Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
Molecular weight 28kDa
Form Lyophilized or Liquid
Concentration 1mg/ml
immunogen KLH conjugated synthetic peptide derived from human ORC6
Lsotype IgG
Purification affinity purified by Protein A
Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail background:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]

Function:
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. ORC6L is a subunit of the ORC complex. It has been shown that ORC6L and and ORC1L are loosely associated with the core complex consisting of ORC2L, 3L, 4L and 5L. Gene silencing studies with small interfering RNA demonstrated that ORC6L plays an essential role in coordinating chromosome replication and segregation with cytokinesis.

Subcellular Location:
Nuclear

Similarity:
Belongs to the ORC6 family.

Database links:

Entrez Gene: 23594 Human

Omim: 607213 Human

SwissProt: Q9Y5N6 Human

Unigene: 49760 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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