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Product Name Anti-MTERFD2/Cy7 Chinese Name Cy7标记的Mitochondrion转录终止因子2抗体 Alias FLJ16261; HSPC096; MGC61716; MTER2_HUMAN; MTERF domain containing 2; mTERF domain-containing protein 2; Mterfd2; OTTHUMP00000200479; OTTHUMP00000200519. Research Area Cell biology immunology Cyclin transcriptional regulatory factor Cell differentiation Mitochondrion Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Rat, (predicted: Human, Mouse, Pig, Cow, Horse, Rabbit, Sheep, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 39kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MTERFD2 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Members of the MTERF (mitochondrial transcription termination factor) family, including MTERF, MTERFD1, MTERFD2 and MTERFD3, are mitochondrial proteins that are that thought to be transcription termination factors. MTERF (mitochondrial transcription termination factor 1) is composed of three leucine zippers that form a three-stranded coiled-coil that binds to DNA. It is suggested that only the phosphorylated form of MTERF has transcription termination activity. MTERFD1 (MTERF domain containing 1) may play a role as a mitochondrial transcription regulator and is expressed as two isoforms produced by alternative splicing. MTERFD2 is a 381 amino acid protein that is encoded by a gene located on human chromosome 2q37.3. MTERFD3 is believed to be involved in cell cycle regulation and cell growth by modulating mitochondrial transcription. MTERFD3 is expressed in heart, skeletal muscle, pancreas and liver.
Function:
Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S).
Subunit:
Heterodimer with NSUN4; this interaction may be required for NSUN4 recruitment to the mitochondrial large ribosomal subunit.
Subcellular Location:
Mitochondrion
Similarity:
Belongs to the mTERF family.
Database links:Entrez Gene: 130916 Human
Entrez Gene: 69821 Mouse
SwissProt: Q7Z6M4 Human
SwissProt: Q8BVN4 Mouse
Unigene: 159556 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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