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Product Name Anti-MRPS18A/Cy7 Chinese Name Cy7标记的Mitochondrion核糖体蛋白S18A抗体 Alias 28S ribosomal protein S18 3 mitochondrial; 28S ribosomal protein S18a mitochondrial; HumanS18b; mitochondrial ribosomal protein S18 3; mitochondrial ribosomal protein S18A; MRP S18 3; MRP S18 a; MRPS18 3; S18bmt; S18mt a. Research Area Cell biology transcriptional regulatory factor Cell type markers Mitochondrion Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 19kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MRPS18A Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S18P family. The encoded protein is one of three that has significant sequence similarity to bacterial S18 proteins. The primary sequences of the three human mitochondrial S18 proteins are no more closely related to each other than they are to the prokaryotic S18 proteins. A pseudogene corresponding to this gene is found on chromosome 3p. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]
Function:
MRPS18A is 1 of more than 70 protein components of mitochondrial ribosomes which are encoded by the nuclear genome. Mitochondria have their own translation system for production of 13 proteins essential for oxidative phosphorylation.
Subcellular Location:
Mitochondrial
Similarity:
Belongs to the ribosomal protein S18P family.
Database links:Entrez Gene: 55168 Human
Omim: 611981 Human
SwissProt: Q9NVS2 Human
Unigene: 520149 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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