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Product Name Anti-phospho-KIF20A (Ser528)/Cy7 Chinese Name Cy7标记的磷酸化有丝分裂驱动蛋白样2抗体 Alias KIF20A (phospho S528); p-KIF20A (phospho S528); GG10 2; GG10_2; Kif20a; kinesin family member 20A; Kinesin like protein KIF20A; Kinesin-like protein 174; mitotic kinesin like protein 2; MKLP2; RAB6 interacting, kinesin like (rabkinesin6); Rab6-interacting kinesin-like protein; RAB6-INTERACTING PROTEIN, KINESIN-LIKE; RAB6KIFL; Rabkinesin 6; AA415432; FLJ21151. Product Type Phosphorylated anti Research Area Cell biology Signal transduction Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Rat, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 100kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthesised phosphopeptide derived from human KIF20A around the phosphorylation site of Ser528 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
The kinesins constitute a large family of microtubule-dependent motor proteins, which are responsible for the distribution of numerous organelles, vesicles and macromolecular complexes throughout the cell (1-3). Individual kinesin members play crucial roles in cell division, intracellular transport, and membrane trafficking events including endocytosis and transcytosis (3,4). KIF1C is a member of the KIF1/Unc104 family of kinesin-like proteins, which are involved in the transport of mitochondria or synaptic vesicles in axons (5). Human KIF1C maps to chromosome 17p13 and encodes a predicted 1,103 amino acid protein with abundant expression in heart and skeletal muscle (5). Tyrosine phosphorylation is a putative regulator of KIF1C mediated retrograde transport of Golgi vesicles to the endoplasmic reticulum (5). KIF1C is capable of forming homodimers and can noncovalently associate with 14-3-3 beta, gamma, epsilon and zeta (6). In mouse macrophages, KIF1C is required for anthrax lethal toxin resistance (7).
Function:
Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and RAB6B. May act as a motor required for the retrograde RAB6 regulated transport of Golgi membranes and associated vesicles along microtubules. Has a microtubule plus end-directed motility.
Subcellular Location:
Golgi apparatus. Cytoplasm > cytoskeleton > spindle.
Post-translational modifications:
Phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle.
Similarity:
Belongs to the kinesin-like protein family.
Contains 1 kinesin-motor domain.
Database links:Entrez Gene: 10112 Human
Entrez Gene: 19348 Mouse
Omim: 605664 Human
SwissProt: O95235 Human
SwissProt: P97329 Mouse
Unigene: 718626 Human
Unigene: 258846 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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