Product Name	Anti-KRT74/Cy7
Chinese Name	Cy7标记的细胞角蛋白74抗体
Alias	CK-74; Cytokeratin-74; K2C74_HUMAN; K5C; K6IRS4; K74; KB37; Keratin; Keratin-5c; Keratin-74; KRT5C; KRT6IRS4; Krt74; type II cytoskeletal 74; Type II inner root sheath-specific keratin-K6irs4; Type-II keratin Kb37.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Dog, Sheep, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	58kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KRT74
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This protein belongs to a family of keratins that are specifically expressed in the inner root sheath of hair follicles.[provided by RefSeq, Jun 2009] Function: Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle. Subunit: Heterotetramer of two type I and two type II keratins. Tissue Specificity: Highly expressed in hair follicles from scalp. In hair, it is specifically present in the inner root sheath (IRS) of the hair follicle. Present in the IRS Huxley layer, but not in Henle layer or cuticle of the IRS. In the IRS Huxley layer, it is expressed in specialized Huxley cells, termed 'Fluegelzellen, along the area of differentiated Henle cells (at protein level). DISEASE: Defects in KRT74 are a cause of woolly hair autosomal dominant (ADWH) [MIM:194300]. A hair shaft disorder characterized by fine and tightly curled hair. Compared to normal curly hair that is observed in some populations, woolly hair grows slowly and stops growing after a few inches. Under light microscopy, woolly hair shows some structural anomalies, including trichorrexis nodosa and tapered ends. Similarity: Belongs to the intermediate filament family. Database links: Entrez Gene: 121391 Human Omim: 608248 Human SwissProt: Q7RTS7 Human Unigene: 660125 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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