Product Name	Anti-KMT5C/Cy7
Chinese Name	Cy7标记的组蛋白赖氨酸N-甲基5C抗体
Alias	FLJ98627; Histone lysine N methyltransferase SUV420H2; KMT5C; Lysine N methyltransferase 5C; MGC2705; Su(var)4 20 homolog 2; SV422_HUMAN; Suppressor of variegation 4 20 homolog 2; Suv4 20h2; SUV420H2.
Product Type	Methylated anti
Research Area	Cell biology  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	52kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human KMT5C
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: SUV420H2 and the related enzyme SUV420H1 (MIM 610881) function as histone methyltransferases that specifically trimethylate nucleosomal histone H4 (see MIM 602822) on lysine-20 (K20) (Schotta et al., 2004 [PubMed 15145825]).[supplied by OMIM, Dec 2009] Function: KMT5C/SUV4-20h2 is a histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. KMT5C/SUV4-20h2 mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. Subunit: Interacts with HP1 proteins CBX1, CBX3 and CBX5. Interacts with RB1 family proteins RB1, RBL1 and RBL2 (By similarity). {ECO:0000250}. Subcellular Location: Nuclear. Similarity: Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily. Database links: Entrez Gene: 84787 Human Entrez Gene: 232811 Mouse SwissProt: Q86Y97 Human SwissProt: Q6Q783 Mouse Unigene: 590982 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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