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Product Name Anti-KGF/Cy7 Chinese Name Cy7标记的纤维母细胞生长因子7抗体 Alias FGF 7; FGF7; FGF-7; Fibroblast Growth Factor 7;HBGF 7; HBGF7; HBGF-7; Keratinocyte growth factor precursor; Heparin binding growth factor 7; Keratinocyte Growth Factor; FGF7_HUMAN; Heparin-binding growth factor 7. Research Area Tumour immunology Signal transduction Growth factors and hormones Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Chicken, Dog, Pig, Sheep, ) Applications
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 18kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from humna KGF Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
KGF is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis.
Function:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
Subunit:
Interacts with FGFBP1. Interacts with FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Subcellular Location:
Secreted.
Tissue Specificity:
Epithelial cell.
Similarity:
Belongs to the heparin-binding growth factors family.
Database links:Entrez Gene: 2252 Human
Entrez Gene: 14178 Mouse
Omim: 148180 Human
SwissProt: P21781 Human
SwissProt: P36363 Mouse
Unigene: 567268 Human
Unigene: 330557 Mouse
Unigene: 98842 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
KGF/FGF7 (Fibroblast growth factor 7) 又称:HBGF-7 纤维母细胞生长因子7,是FGF家族的主要成员之一。
FGF家族参与细胞生长、组织修复、胚胎生长发育、组织器官的形成、Tumour的生长和侵润等诸多生理病理功能。
成纤维细胞生长因子7的促增生作用主要来源于角化epithelial cells而不是间质细胞和endothelial cells,因此人们又称之为:角化epithelial cells生长因子(KGF)。
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