Product Name	Anti-CIDEB/Cy7
Chinese Name	Cy7标记的CIDEB抗体
Alias	cell death activator CIDE-B; Cell death activator CIDE B; Cell death inducing DFFA like effector B; CIDEB_HUMAN; cell death-inducing DFFA-like effector B; Cide-b.
Research Area	Tumour  Cell biology  Chromatin and nuclear signals  Apoptosis  Cyclin
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
Applications	not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	24kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CIDEB (115-160aa)
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases. These death signals finally cause the degradation of chromosomal DNA by activated DNase. DFF45/ICAD has been identified as an inhibitor of caspase activated DNase DFF40/CAD. DFF45 related proteins CIDE A and CIDE B were recently identified. CIDE contains a new type of domain termed CIDE N, which has high homology with the regulatory domains of DFF45/ICAD and DFF40/CAD. Expression of CIDE B induces apoptosis, which is inhibited by DFF45. CIDE B is a DFF45 inhibitable effector that promotes cell death and DNA fragmentation. CIDE B is expressed mainly in liver and small intestine and at lower levels in spleen, colon, kidney, peripheral blood lymphocytes, and bone marrow. Function: Activates apoptosis. Subunit: Inhibited by DFFB. Interacts with DFFA and DFFB. Tissue Specificity: Highly expressed in liver and small intestine and, at lower levels, in colon, kidney and spleen. Similarity: Contains 1 CIDE-N domain. Database links: Entrez Gene: 27141 Human Entrez Gene: 12684 Mouse Entrez Gene: 364388 Rat Omim: 604441 Human SwissProt: Q546V8 Human SwissProt: Q9UHD4 Human SwissProt: O70303 Mouse Unigene: 642693 Human Unigene: 696081 Human Unigene: 708040 Human Unigene: 466766 Mouse Unigene: 204016 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CIDEB是在Apoptosis的过程中诱导分泌的一种蛋白，在棕色脂肪组织，肝脏和肾脏中发现有高水平的DFF45-like effector--DFF45样效应子b蛋白，简称cideb。CIDEB具有调控脂质代谢的作用。

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